211. Outcomes Following a Protocol Change to decrease Perioperative Antibiotic Duration Among Liver Transplant Recipients
نویسندگان
چکیده
Abstract Background Liver transplant recipients (LTRs) are at high risk for infections. The optimal duration of perioperative antibacterial prophylaxis remains unclear, particularly in patients hospitalized prior to transplant. Our study examines the impact a change our institutional antibiotic protocol LTRs on post-transplant infection and antibiotic-associated toxicity. Methods We conducted retrospective cohort all adult center who underwent from 1/1/2018 until 9/1/2021. Patients were categorized as low if they < 24 hours ≥ investigated patient outcomes after guideline 1/19/21, which reduced post-operative antibiotics 48 5 days or ICU stay 72 hours. Outcomes included within 30 (composite outcome bacteremia surgical site infection), C. difficile (CDI), isolation multi-drug resistant organisms (MDROs) any site. Chi-squared Fisher’s exact test performed with p 0.05 considered significant. Results There 154 transplantation during period, including 63 (43 before 20 change). median prophylactic group decreased 6 (IQR 5-8) 4.5 4-5) (p = 0.04), 2.5 2-5) 1 1-2) day 0.04). Prophylactic consisted piperacillin-tazobactam 145 (94%) vancomycin 104 (68%) cases. In group, occurred 4 (9%) 0 (p=0.3). CDI (5%) (p=1). Resistant isolated 10 (23%) (p=0.15). Figure 1.Antibiotic percentage each cohortTable 1.Clinical among patientsTable 2.Antibiotic-associated Conclusion policy but was not accompanied by an observed increase postoperative infection. Disclosures All Authors: No reported disclosures.
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2022
ISSN: ['2328-8957']
DOI: https://doi.org/10.1093/ofid/ofac492.288